{"id":2858,"date":"2020-03-26T04:42:41","date_gmt":"2020-03-26T09:42:41","guid":{"rendered":"https:\/\/ami.advancedrenaleducation.com\/wparep\/?post_type=article&#038;p=1239"},"modified":"2025-05-09T16:11:40","modified_gmt":"2025-05-09T21:11:40","slug":"metabolic-acidosis","status":"publish","type":"article","link":"https:\/\/ami.advancedrenaleducation.com\/wparep\/asiapacific\/article\/metabolic-acidosis\/","title":{"rendered":"Metabolic Acidosis"},"content":{"rendered":"<div id=\"dnn_ctr710_HtmlModule_lblContent\" class=\"Normal\">\n<ul>\n<li>Can occur accidentally as a consequence of dialysate fluid containing improper ratios of acid and base concentrates in the form of acetate or bicarbonate<sup>1,2.<\/sup><\/li>\n<li>Can also develop as a result of the accidental use of an acidic concentrate instead of acetate or bicarbonate and due to computer software malfunction of the machine<\/li>\n<li>Severe metabolic acidosis has been reported during first 2 hours of HD using sorbent regenerative hemodialysis in mechanically ventilated patients<sup>3<\/sup><\/li>\n<li>Treatment consists of intravenous administration of bicarbonate and dialysis with bicarbonate dialysate of a correct concentration (38-40 mEq\/L)<\/li>\n<li>The mainstay of prevention is to fit all HD machines with a pH meter and alarms that will prevent the extreme acid load, which may be caused by an inappropriately prepared bicarbonate dialysate. Conductivity checks are vital.<\/li>\n<\/ul>\n<div class=\"vcex-spacing\" style=\"height:30px\"><\/div><div class=\"vcex-module vcex-divider vcex-divider-solid\" style=\"width:100%;margin-top:20px;margin-bottom:20px;border-top-width:1px;border-color:#dddddd;\"><\/div>\n<h4>References:<\/h4>\n<ol>\n<li>Hartmann A, Reisaeter A, Holdaas H, Rolfsen B, Fauchald P. Accidental metabolic acidosis during hemodialysis. <em>Artif Organs<\/em> 18:214-217, 1994<\/li>\n<li>Gainza FJ, Zarraga S, Minguela I, Lampreabe I. Accidental substitution of acid concentrate for acetate in dialysis fluid concentrate: A cause of severe metabolic acidosis. <em>Nephron<\/em>\u00a069:480-482, 1995<\/li>\n<li>Reyes A, Turchetto E, Bernis C, Cereijo E. Acid-base derangements during sorbent regenerative hemodialysis in mechanically ventilated patients. <em>Crit Care Med<\/em>\u00a019:554-559, 1991<\/li>\n<\/ol>\n<div class=\"vcex-spacing\" style=\"height:30px\"><\/div>\n<\/div>\n","protected":false},"featured_media":0,"template":"","format":"standard","meta":{"_acf_changed":false},"categories":[128],"tags":[60],"language":[41],"articles":[230],"class_list":["post-2858","article","type-article","status-publish","format-standard","hentry","category-articles","tag-intradialytic","language-english","articles-hemodialysis","entry","no-media"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Metabolic Acidosis - AREP Asia Pacific<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ami.advancedrenaleducation.com\/wparep\/article\/metabolic-acidosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Metabolic Acidosis - AREP Asia Pacific\" \/>\n<meta property=\"og:description\" content=\"Can occur accidentally as a consequence of dialysate fluid containing improper ratios of acid and base concentrates in the form of acetate or bicarbonate1,2. 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